Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, medicinal chemistry of nucleic acids presents a thorough overview of nucleic acid chemistrya rapidly evolving and highly challenging discipline. Functional nucleic acids for analytical applications yingfu. A free online book on the chemistry and biology of nucleic acids, written by prof. Nucleic acid templated chemistry natc, or dnatemplated chemistry, is a tool used in the controlled synthesis of chemical compounds. Medicinal chemistry of nucleic acids wiley online books. The conformation of biological macromolecules their biophysical chemistry. Nucleic acids book chemistry and biology of nucleic acids. It serves well as a textbook by introducing basic materials in a larger scope. Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, medicinal chemistry of nucleic acids presents a thorough overview of nucleic acid chemistry. Davidson chargaff and a great selection of related books, art and collectibles available now at.
The structure of dna differs from rna only because the dna molecule does not have a hydroxyl group on the 2 carbon atom of the sugar ring. Deoxyribonucleic acid dna and ribonucleic acid rna are the two types of nucleic acids. Nucleic acids are the biopolymers, or small biomolecules, essential to all known forms of life. In summary, this book provides an excellent overview of the chemistry and biology of nucleic acids, at a level that is suitable for use in university teaching, but with enough detail to be useful as a reference source for chemists, biochemists and biologists involved in current research of nucleic acids. The book is ideal for chemistry and biology students and also provides practical information for researchers working in the lab. Sequencing, cloning, transcription these are but a few key techniques behind the current breathtaking advances in molecular biology and. It will help readers to get a sound understanding of the chemistry, its implications, consequences and applications. This 2nd edition text integrates the chemistry and biology of the nucleic acids and sets the basics in the context of the expanding horizons set by modern structural biology, enzymology, drug discovery and biotechnology. Nucleic acid, naturally occurring chemical compound that is capable of being broken down to yield phosphoric acid, sugars, and organic bases.
Include an initiation codon and a termination codon. The biophysical chemistry of nucleic acids download ebook. In summary, this book provides an excellent overview of the chemistry and biology of nucleic acids, at a level. As the title indicates, the book has broad coverage of many facets of nucleic acids. Aug 12, 2019 both nucleic acidsdna and rnaare polymers composed of monomers known as nucleotides, which in turn consist of phosphoric acid h 3 po 4, a nitrogenous base, and a pentose sugar. Loakes, david hardcover medical book nucleic acids in chemistry and biology nowhere is this more apparent than in the increasing efforts to determine the dna sequence of the human genome and the development of new diagnostics of genetic disease. Chemical aspects of nucleic acids come to the fore in the last third of the book, with description of interactions of small molecules with nucleic acids, protein nucleic acid interactions and techniques used to analyse nucleic acids. The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. This book contains five chapters and begins with the susceptibility of nucleic acids towards attack by chemical reagents whose reactions with polynucleotides have. The missing hydroxyl group keeps dna from being hydrolyzed, making it more stable than the ribose sugar of rna. The biophysical chemistry of nucleic acids and proteins photochemistry of proteins and nucleic acids amino acids. Current protocols in nucleic acid chemistry is the comprehensive resource for detailed protocols related to the synthesis, modification, and analysis of modified and unmodified nucleosides, nucleotides, oligonucleotides, and nucleic acids. Basic principles in nucleic acid chemistry sciencedirect. The structure, function and reactions of nucleic ac.
When the first edition of this book was published in 1950, it set out to present an elementary outline of the state of knowledge of nucleic acid biochemistry at that time and it was the first monograph on the subject to appear since levenes book on nucleic acids in 1931. Current protocols in nucleic acid chemistry wiley online. This edited book, nucleic acids from basic aspects to laboratory. This is the first book to provide a comprehensive overview of the field of artificial nucleic acids. Nucleic acids exercises problems and select solutions for the chapter. The biochemistry of the nucleic acids sciencedirect. Covering a tremendous amount of literature on the chemistry, biology, and structure of artificial nucleic acids, it will constitute an invaluable source of information for the specialist and for young researchers interested in starting a career in this fascinating field of research alike. The biochemistry of the nucleic acids provides an elementary outline of the main biochemical features of nucleic acids and nucleoproteins. The main advantage of nat chemistry natc is that it allows one to perform the chemical reaction as an intramolecular reaction. Nucleic acids are the main informationcarrying molecules of the cell and play a central role in determining the inherited characteristics of every living thing.
This text is organized into 14 chapters and begins with a historical overview, from. Since the discovery of the dna double helix in 1953, nucleic acids have formed the central theme of much of contemporary molecular science. Feb 21, 1991 nucleic acids in chemistry and biology book. Revised and updated nucleic acids in chemistry and biology 3rd edition discusses in detail, both the chemistry and biology of nucleic acids and brings rna into parity with dna. Teaching a course on nucleic acid structure is a hazardous undertaking, especially if. This book is licensed under a creative commons byncsa 3. The 2020 nucleic acids research database issue contains 148 papers spanning molecular biology. Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, medicinal chemistry of nucleic acids presents a thorough overview of nucleic acid chemistry a rapidly evolving and highly challenging discipline directly. The biochemistry of the nucleic acids springerlink. This is nucleic acids, chapter 19 from the book introduction to chemistry. The book covers the chemistry of nucleic acids and its components impressively well in different chapters. This study provides a general introduction to the chemistry and biology of nucleic acids, in a style easily readable by those with a basic scientific background. Advanced organic chemistry of nucleic acids wiley online books.
Dna is metabolically and chemically more stable than rna. Nucleic acids in chemistry and biology book depository. The key concept is that some form of nucleic acid is the genetic material, and these encode the macromolecules that function in the cell. The book describes the occurrence and biological functions of nucleic acids, their chemical constituents, and catabolism. The two types of nitrogenous bases most important in nucleic acids are purines adenine a and guanine gand pyrimidines cytosine c, thymine t, and. This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology.
Nucleic acids are the main informationcarrying molecules of the cell, and, by directing the process of protein synthesis, they determine the inherited characteristics of every living thing. Nucleic acids play principal roles in the storage and transmission of genetic information within cells. Nucleic acids dna rna are long chains of repeated nucleotides a nucleotide consists of. Nowhere is this more apparent than in the increasing efforts to determine the dna sequence of the human genome and the development of new diagnostics of genetic disease. Nucleic acids book chemistry and biology of nucleic acids atdbio.
Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, medicinal chemistry of nucleic acids presents a thorough overview of nucleic acid chemistrya rapidly evolving and highly challenging discipline directly. Nucleic acids in chemistry and biology book, 1996 worldcat. Basic principles in nuclear acid chemistry, volume ii presents the significant progress in nucleic acid research and its contribution and influence on various aspects of human life. The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of. Everything you need to know essential amino acids nonessential amino acids too. Nucleic acids in chemistry and biology rsc publishing. The amino acid sequence for bradykinin is argproproglypheserprophearg. Chemical aspects of nucleic acids come to the fore in the last third of the book, with description of interactions of small molecules with nucleic acids, proteinnucleic acid interactions and techniques used to analyse nucleic acids. Rna is the nucleic acid responsible for using the genetic information in dna to produce proteins. Postulate a base sequence in the mrna that would direct the synthesis of this hormone. Bradykinin is a potent peptide hormone composed of nine amino acids that lowers blood pressure. Structures of nucleic acids some genomes are rna some viruses have rna genomes. Nucleotides are joined together to form nucleic acids through the phosphate group of one nucleotide connecting in an ester linkage to the oh group on the third carbon atom of the sugar unit of a. Both nucleic acidsdna and rnaare polymers composed of monomers known as nucleotides, which in turn consist of phosphoric acid h 3 po 4, a nitrogenous base, and a pentose sugar.
Tom brown, winner of the 2009 rsc interdisciplinary prize and author of over 250 papers and patents on nucleic acid research, including dna structure, chemical ligation using click chemistry. Structural biochemistryorganic chemistrynucleic acids dna. Chemical biology of nucleic acids fundamentals and clinical. This book consists of 15 chapters contributed by experts in the field of functional nucleic acids, mostly in the area of specific analytical applications of nucleic acids. Nucleic acids in chemistry and biology, used abebooks. Nucleic acids are central to much of contemporary molecular science. Both nucleic acids dna and rnaare polymers composed of monomers known as nucleotides, which in turn consist of phosphoric acid h 3 po 4, a nitrogenous base, and a pentose sugar. Click download or read online button to get the biophysical chemistry of nucleic acids book now. The exceptionally important role of the nucleic acids as a key to the understanding of the nature of life is reflected in the enormous number of published works on the subject, including many outstanding monographs and surveys. Nucleic acids in chemistry and biology 3, blackburn, g. The term nucleic acid is the overall name for dna and rna.
Nucleic acids in chemistry and biology rakuten kobo. Chemistry and biology of artificial nucleic acids wiley. Nucleic acid, naturally occurring chemical compound that is capable of being broken down to yield phosphoric acid, sugars, and a mixture of organic bases purines and pyrimidines. Nucleic acids in chemistry and biology pdf medical books. Choose from 500 different sets of organic chemistry nucleic acids flashcards on quizlet. Jun 25, 2011 nucleic acids in chemistry and biology 3rd edition by blackburn, g. Organization of genetic material, semiconservative nature of dna synthesis, the chemistry of dna synthesis, the proteins of dna synthesis, dna repair, properties of the three major rna species and rna synthesis. Vella, biochemical education 192 1991 the text is well written, clearly laid out, with good illustrations, and an emphasis on how the chemistry of nucleic acids explains the biology of nucleic acids. Jul 25, 2011 complete, uptodate coverage of the broad area of nucleic acid chemistry and biology. Nucleic acids from basic aspects to laboratory tools intechopen. The typical synthetic methods of nucleoside, nucleotide and oligonucleotide analogues are presented clearly with. Complete, uptodate coverage of the broad area of nucleic acid chemistry and biology. They are composed of nucleotides, which are the monomers made of three components.
The book will also find a place on the shelf of many whose research investigations are on one or another aspect of nucleic acids. Chapter 2 structures of nucleic acids nucleic acids. The study of nucleic acids is one of the most rapidly developing fields in modern science. The 2019 web server issue of nucleic acids research is the. With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained. Among them, 59 are new and 79 are updates describing resources that appeared in the issue previously. The remaining 10 cover databases most recently published elsewhere. Learn organic chemistry nucleic acids with free interactive flashcards. Nucleic acids in chemistry and biology book, 1990 worldcat. Jan 15, 2007 the structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Physical chemistry of dnathe problems of dna research. The biophysical chemistry of nucleic acids and proteins. The chemical biology of nucleic acids wiley online books.
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